Union Civil Aviation Ministry (MoCA) clears Al Hind Air, FlyExpress, Shankh Air to break IndiGo-Air India duopoly.
[Union Civil Aviation Ministry (MoCA), Al Hind Air, FlyExpress, Shankh Air, IndiGo, Air India]
Key Updates:
- Al Hind Air and FlyExpress received no-objection certificates from the Union Civil Aviation Ministry this week.
- Uttar Pradesh-based Shankh Air already holds an NOC and targets commercial launch in 2026.
- IndiGo and the Air India Group together control more than 90% of India’s domestic market, with IndiGo alone exceeding 65%.
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- The Ministry of Civil Aviation (MoCA) has given no objection certificates (NOCs) to three airlines – Al Hind Air, FlyExpress and Shankh Air – to provide more choice for consumers and bring down the cost of flights.
- Shankh Air, which aims to be the leading full-service airline of Uttar Pradesh, plans to launch its flight services around the first quarter of 2026.
- Al Hind Air, owned by the Kerala-based Alhind Group, has an initial investment between Rs 200 and Rs 500 crore and will focus on domestic and regional travel using ATR 72-600 model aircraft.
- FlyExpress, which received its NOC from the MoCA, is reportedly backed by a courier and cargo services company from Hyderabad.
- To begin operations, these carriers must next get an Air Operator Certificate (AOC) from the Directorate General of Civil Aviation (DGCA) by proving they have financial backing, aircraft, and trained crew.
- IndiGo’s weekly domestic departures were approved at 15,014 for the winter schedule.
- IndiGo actually operated 59,438 flights in November 2025 against 64,346 approved domestic flights.
- The airline recorded 951 flight cancellations during November 2025.
- IndiGo could operate only 339 aircraft in October 2025 and 344 aircraft in November 2025 against an estimated 403 aircraft.
- The 10% cut translates to a minimum reduction of 216 daily flights from the summer level of over 2,200 daily flights.
- Air India and Air India Express weekly domestic flights were reduced by 0.8% and 6% respectively from summer to winter schedule.
- Akasa Air’s weekly domestic schedule reduced by 5.7% from 1,089 to 1,027 flights.
- SpiceJet increased weekly domestic flights by over 26% from 1,240 to 1,568.
- Air India has been recognised as the ‘Best Domestic Airline’ at the Travel + Leisure India and South Asia’s Best Awards 2025, for the second consecutive year.
- The recognition is decided through a customer vote and reflects the trust placed in Air India by its patrons.
- The award underscores the strides made by Air India in delivering an elevated product and service experience across touchpoints for millions of passengers.
- Air India is investing significantly in modernising its fleet and enhancing customer experience, including a USD 400 million retrofit programme to refurbish existing aircraft cabins.
- The Directorate General of Civil Aviation (DGCA) revoked its directive that barred airlines from substituting pilots’ weekly rest days with leave.
- The regulator cited 'ongoing operational disruptions' and 'repeated representations from airlines seeking flexibility to maintain the continuity and stability of operations'.
- DGCA has also directed its own inspectors, who are hired on five-year contracts as auditors and barred from flying for commercial carriers, to operate IndiGo flights.
NATGRID-NPR Integration enables real-time access to 119 crore residents' family details
[NATGRID, Government of India]
Key Updates:
- The National Intelligence Grid (NATGRID) has been linked to the National Population Register (NPR) which stores family-wise details of 119 crore residents.
- Access to NATGRID is now extended to Superintendent of Police-rank officers; earlier it was limited to ten Central agencies.
- The upgraded tool 'Gandiva' supports facial recognition and entity resolution by matching suspect images with photo identity documents.
Similar / Past Coverage
- The Centre has proposed shared network access for power distribution.
- Raj and the International Solar Alliance will build the country’s first digital power network.
- Experts propose solar panels for low-income neighbourhoods.
- NATGRID is a platform for police and investigating agencies to securely access government and private databases in real time.
- The platform receives around 45,000 requests a month.
- Access is now available to Superintendent of Police (SP) rank officers, expanded from the earlier restriction to ten central agencies.
- The Union Ministry of Home Affairs (MHA) has asked States to use NATGRID to access datasets including driving license, Aadhaar registration, airline data, bank records, and social media account details.
- NeVA is a Mission Mode Project under the Digital India programme.
- 28 State and Union Territory Legislatures have signed MoUs for its adoption.
- 20 have already become fully digital Houses.
- NeVA enables complete backend computerisation of Legislature Secretariat branches.
- Ministry of Parliamentary Affairs provides ICT infrastructure, training and continuous technical handholding.
- NeVA offers a unified digital architecture for all 37 State/UT Legislatures.
- Bhashini-powered AI tools enable text translation, speech-to-text and voice-to-speech.
- The Telecom Centres of Excellence TCoE has signed agreements with leading implementation partners to roll out the Samriddh Gram Phygital Services Pilot.
- The initiative is designed to seamlessly integrate physical infrastructure with digital services across rural communities, leveraging BharatNet connectivity to deliver essential citizen-centric services, bridging the urban-rural digital divide and driving sustainable development at the grassroots level.
- The Samriddh Gram Phygital Services Pilot represents a bold new model of “phygital transformation,” merging physical presence with digital platforms.
- The Department of Telecommunications DoT has identified three pilot villages for this initiative: Chaksu, Rajasthan; Khatav, Maharashtra; and Kolar, Karnataka.
- Each of these villages will host a Samriddhi Kendra—a state-of-the-art integrated service hub that serves as the focal point for local citizens to access digital education, healthcare, governance, and economic opportunities.
- Each Samriddhi Kendra will act as a comprehensive service hub, integrating multiple sectors through digital innovation, including Education and Skilling, Agriculture, Healthcare, e-Governance, E-Commerce and Entrepreneurship, Financial Inclusion, and Connectivity Backbone.
- The implementation partners for the pilot include: Centre for Development of Advanced Computing (C-DAC), Indian Institute of Technology, Madras (IIT-M), Indian Institute of Technology, Delhi (IIT-D), Indian Institute of Management, Ahmedabad (IIM-A), Indian Institute of Management, Bangalore (IIM-B), Indian Institute of Management, Calcutta (IIM-C), National Institute of Financial Management (NIFM), and National Institute of Smart Governance (NISG).
- Following successful implementation and impact evaluation, the model is expected to be scaled up nationwide, with plans to establish hundreds of Samriddhi Kendras across India’s 6 lakh villages.
EPFO Single-Window Service Centres Revamp
[EPFO, Government of India]
Key Updates:
- Union Minister for Labour and Employment and Youth Affairs and Sports, Mansukh Mandaviya, announced that EPFO offices will be revamped into modern, technology-enabled, single-window service centres.
- All upcoming and several existing EPFO offices will be redesigned on the lines of passport seva kendras, allowing citizens to resolve any EPF-related issue at any regional office nationwide.
- EPFO will undertake mission-mode KYC verification and launch a dedicated digital platform for simplified claim filing and faster settlements.
- Claims up to ₹5 lakh are now settled automatically and withdrawals of up to 75 percent of EPF balances have been eased.
- EPFO will introduce EPF Suvidha Providers—authorised facilitators to assist members in accessing benefits and resolving grievances.
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- The Assessment Report of Special Campaign 5.0 and the Annual Report of CPGRAMS were released by Dr. Jitendra Singh, Minister of State for Personnel, Public Grievances and Pensions.
- Special Campaign 5.0 institutionalised Swachhata and reduced pendency across government offices, generating over Rs 4100 crores through systematic disposal of scrap and e-waste.
- CPGRAMS report highlights the Government’s focus on responsive, technology-enabled and time-bound grievance redressal.
- The Employees' Provident Fund Organisation has set up a four-member committee for cadre restructuring of the retirement fund body.
- The committee, headed by BP Sharma, the former secretary of the department of personnel and training, will submit its report by March 31, 2026.
- It will undertake a comprehensive review of the existing workload of EPFO, identify imbalances, overlaps and inefficiencies in the present workforce structure and evaluate the requirement for rationalisation, optimisation or augmentation of human resources in line with functional necessities.
- The committee will benchmark the cadre structure of officers and employees of the central board and recommend appropriate restructuring measures to enhance efficiency, service delivery and institutional effectiveness, while ensuring that manpower deployment remains commensurate with the functional workload.
- It will recommend a suitable framework for induction of officers on deputation from the central government and other public institutions for bringing in talent, best practices, and cross-sectoral expertise to EPFO.
- The committee will also recommend a framework for EPFO officers and staff to go on deputation or exchange programmes to other organisations to facilitate exposure to new ideas, professional development, and adoption of innovative practices.
- The Pension Fund Regulatory and Development Authority (PFRDA) notified amendments to the PFRDA Exits and Withdrawals Regulations, 2015, applicable to the National Pension System (NPS).
- The permissible lump-sum withdrawal at normal exit has been increased from 60% to 80%, while the mandatory annuity portion has been reduced to 20%.
- The maximum exit age for subscribers has been extended from 70 years to 85 years.
- For the All Citizen Model, normal exit is now permitted after 15 years of investment or upon reaching 60 years of age, whichever is earlier.
- The threshold for 100% lump-sum withdrawal for non-government subscribers has been raised from ₹5 lakh to ₹8 lakh.
- The mandatory 5-year minimum subscription period previously required for premature exit has been removed for non-government subscribers.
- New structured withdrawal mechanisms, namely Systematic Lumpsum Withdrawal (SLW) and Systematic Unit Withdrawal (SUR), have been introduced to allow periodic redemption of investment units.
- For government subscribers with a corpus between ₹8 lakh and ₹12 lakh, a lump-sum withdrawal of up to ₹6 lakh is permitted, with the remainder accessible via SUR.
- The list of permitted reasons for partial withdrawal has been liberalized to include medical treatment without restriction to a specific list of illnesses.
- City Union Bank (CUB) has tied up with the Employees’ Provident Fund Office (EPFO) for remittance of EPF payments.
- The EPF payment facility was officially launched by R. Vijay Anandh, executive director, CUB, and Maneesh Agnihotri, Regional PF Commissioner, Tamil Nadu, in Chennai.
- Many MSMEs and SMEs within CUB's network would be the primary focus for clients targeted by the bank.
- This EPF remittance facility will enable the employers with CUB accounts to make the EPF remittance seamlessly through net banking.
Saudi-led coalition warns Southern Transitional Council against military moves undermining Yemen de-escalation
[Saudi-led coalition, Southern Transitional Council, Yemen]
Key Updates:
- Saudi-led coalition spokesman Brigadier General Turki al-Maliki stated 'any military movements that violate these [de-escalation] efforts will be dealt with directly and immediately'.
- Saudi Defence Minister Khalid bin Salman posted on X that 'it’s time' for STC troops 'to let reason prevail by withdrawing from the two provinces and doing so peacefully'.
- The STC accused Saudi Arabia of launching air strikes on its positions in Hadramout province.
- US Secretary of State Marco Rubio urged 'restraint and continued diplomacy, with a view to reaching a lasting solution'.
- Yemen’s government requested the Saudi-led coalition 'to take all necessary military measures to protect innocent Yemeni civilians in Hadramout province and support the armed forces'.
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- Pakistan's Chief of Defence Forces, Field Marshal Syed Asim Munir, was awarded the King Abdulaziz Medal of Excellence, the highest national honour of the Kingdom of Saudi Arabia (KSA).
- The award was conferred under a Royal Decree issued by the Custodian of the Two Holy Mosques, King Salman bin Abdulaziz Al Saud.
- The Saudi leadership recognized Field Marshal Munir for his professionalism, strategic outlook, and commitment to strengthening ties between Pakistan and the KSA.
- During his official visit, Field Marshal Munir also met with Prince Khalid bin Salman bin Abdulaziz Al Saud, the Minister of Defence of the KSA, to discuss regional security and military cooperation.
- India reaffirmed its commitment to the ideals of Vasudhaiva Kutumbakam and religious harmony at the 11th United Nations Alliance of Civilizations (UNAOC) forum.
- The Indian delegation was led by P Kumaran, Secretary (East) of the Ministry of External Affairs (MEA).
- The forum was hosted by Saudi Arabia in Riyadh from December 14 to 15, 2025.
- The Indian representative highlighted the nation's civilizational heritage and the long-standing belief in Sarva Dharma Samabhav, which stresses equal respect for all faiths.
- The gathering marked two decades of the UNAOC and brought together political leaders, religious representatives, civil society, youth, and media to address global divisions.
- Indian Ambassador to Saudi Arabia Suhel Ajaz Khan and Abdulmajeed bin Rashed Alsmari, Deputy Minister for Protocol Affairs of the Ministry of Foreign Affairs of Saudi Arabia, signed the bilateral Visa Waiver Agreement.
- The agreement covers holders of diplomatic, special and official passports and aims to facilitate official travels and boost bilateral exchanges under the India-Saudi Arabia Strategic Partnership Council.
- Lok Sabha Speaker Om Birla announced that the Parliament of India will soon constitute the India-Saudi Arabia Parliamentary Friendship Group.
- Major General Abdul Rahman bin Sanhat Al-Harbi, Chairman of the Saudi-India Parliamentary Friendship Committee from the Shura Council of the Kingdom of Saudi Arabia, met with Speaker Birla to emphasize parliamentary diplomacy and institutional collaboration.
- The U.S. military launched retaliatory strikes on Friday against dozens of ISIS targets in Syria.
- More than 70 ISIS targets were struck using over 100 munitions from fighter jets, attack helicopters and rocket artillery.
- Jordanian fighter aircraft also participated in the strikes.
- The operation named 'Operation Hawkeye Strike' was carried out in response to the attack on U.S. forces in Palmyra, Syria.
- The strikes targeted ISIS weapon areas and infrastructure in central Syria.
- There are currently 1,000 U.S. troops in Syria, mostly in eastern Syria.
- The U.S. estimates between 1,500 to 3,000 ISIS militants remain active in Syria and Iraq.
University of Technology Sydney (UTS) team crafts mild mitochondrial uncouplers that raise cellular calorie burn
[University of Technology Sydney (UTS)]
Key Updates:
- Researchers at the University of Technology Sydney (UTS) have developed experimental drugs aimed at enhancing the efficiency of mitochondria, the 'powerhouses' of cells, to burn more calories.
- The research team from UTS and Memorial University of Newfoundland focused on a class of compounds known as mitochondrial uncouplers.
- These molecules alter how cells utilize energy, prompting them to burn energy less efficiently and instead release it as heat.
- By adjusting the chemical structure of these molecules, researchers could fine-tune their effects on cellular energy expenditure.
- Some experimental drugs successfully enhanced mitochondrial activity without causing harm to cells or disrupting their ability to produce ATP.
- These compounds may lower oxidative stress within cells, potentially improving metabolic health, offering anti-aging benefits, and providing protection against neurodegenerative diseases such as dementia.
Similar / Past Coverage
- Researchers at the Institute of Nano Science and Technology (INST), Mohali, have identified a new pathway involving nanoparticles to treat Alzheimer's Disease (AD).
- The therapy involves nanoparticles that integrate epigallocatechin-3-gallate (EGCG) -- an antioxidant found in green tea --, dopamine -- a neurotransmitter important for mood -- and tryptophan -- an amino acid involved in many cellular functions -- into a nanoparticle called EGCG-dopamine-tryptophan nanoparticles (EDTNPs).
- Incorporation of Brain-Derived Neurotrophic Factor (BDNF) -- a protein crucial for the survival, growth, and function of neurons onto EDTNPs (B-EDTNPs) creates a dual-action nanoplatform that not only clears neurotoxic Amyloid Beta aggregates but also enhances neuronal regeneration.
- The research involves the synthesis of EDTNPs using biocompatible assembly techniques like pressure-assisted hydrothermal and electrostatic-based co-incubation methods to combine antioxidant, neurotransmitter, and amino acid components.
- The therapy enables it to simultaneously target amyloid aggregation, oxidative stress, inflammation, and neuronal degeneration -- four key pathological hallmarks of Alzheimer's.
- Researchers at Texas A&M University used nanoflowers made from molybdenum disulfide to scavenge reactive oxygen species and stimulate stem cells to produce surplus mitochondria.
- The surplus mitochondria were naturally transferred to old, damaged neighboring cells, restoring energy levels without genetic manipulation.
- In lab tests, mitochondria transfer rates doubled, heart smooth-muscle cell numbers rose three-to-four-fold, and chemotherapy-damaged heart cells showed significantly higher survival.
- The Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bengaluru an autonomous institute of Department of Science and Technology (DST) and CRISPRBITS Private Limited (CrisprBits) based in Delhi... have announced the signing of a Letter of Intent (LOI) to jointly establish the CoE-CIT.
- The CoE-CIT is envisioned to bridge the bench to bed gap leading and have therapeutic impact by combining JNCASR’s strengths in fundamental biomedical sciences with CrisprBits’ expertise in applied gene-editing and translational platforms.
- The CoE-CIT is a dedicated hub to harness cutting-edge CRISPR technologies to facilitate translation of scientific discoveries in a laboratory into real-world clinical applications.
- The CoE will serve as a replicable national model for academic–industry partnerships to strengthen India’s biotechnology and innovation ecosystem.
- Synergizing the mutual strengths in genetics, molecular and chemical biology, and computational biology, this unique partnership will open a new route to impact society and national missions.
- Russian teenagers are turning to a viral weight-loss pill named Molecule.
- This pill is sold illegally and contains a banned substance linked to heart problems.
- Users report severe side effects including anxiety, insomnia, dry mouth, loss of appetite, dilated pupils, and tremors.
- Although the packaging lists natural ingredients, the pills were found to be contaminated with sibutramine.
- Sibutramine, previously used as an antidepressant and appetite suppressant, was banned in many countries due to increasing the risk of heart attacks and strokes.
- In Russia, sibutramine is available to adults via prescription for obesity, but purchasing and selling it without one is a criminal offense.
- Self-administering the drug is highly unsafe as the amount of active ingredient in it remains unknown.
- After prison sentences for purchasing and reselling, Molecule pills were removed from sale but later launched under the new name Atom.
- Molecule pills are marketed as a weight loss supplement with banned substances and unknown quantities, differing from FDA-approved prescription GLP-1 drugs like Ozempic.
- The pills are popular among young Russians because they are significantly cheaper than recognized weight-loss injections like Ozempic.
Banaras Hindu University (BHU) researchers unveil first molecular classification of oral cancer for precision therapy
[Banaras Hindu University (BHU)]
Key Updates:
- Banaras Hindu University (BHU) researchers analysed over 8,000 scientific articles and genomic data to create the world’s first systematic molecular classification of oral cancer.
- The study identifies five distinct biological groups: Cell-Cycle Dysregulation (CCD), Immune-Mediated (IM), Xenobiotic Metabolism-Associated (XMA), Inflammatory Pathway Activation (IPA), and Viral Protein Activation (VPA).
- Each group is directly linked to specific actionable genes and pathways, guiding clinicians to select targeted therapies such as HER2 inhibitors, PARP inhibitors, or specific immunotherapies.
- Unlike Western classifications, this model emphasises pathways influenced by tobacco and betel quid use (XMA and IPA), making it highly relevant for the Indian population.
- The classification clarifies that HPV is a minor driver in most Indian oral cancers, preventing the misapplication of Western treatment protocols.
Similar / Past Coverage
- An India-led research study has shown that radiation therapy after surgery safely reduces the risk of relapse for bladder cancer.
- It is a post-operative treatment used for patients with high-risk, muscle-invasive bladder cancer to reduce the risk of recurrence in the pelvic area.
- Dr Vedang Murthy, professor of Radiation Oncology at Tata Memorial Centre (TMC), is the principal investigator of the bladder adjuvant radiotherapy trial.
- The Bladder Adjuvant Radiotherapy (BART) trial is the largest randomised trial in the world to evaluate the role of radiation therapy after bladder cancer surgery.
- The trial enrolled more than 150 patients across four cancer centres in India between 2016 and 2024.
- Results showed a marked reduction in potentially painful local cancer recurrences among patients who received radiation after surgery, without an increase in side effects.
- The study observed a consistent 12–15% absolute improvement with radiotherapy in disease-free survival, cancer-specific survival and overall survival.
- Scientists at the S N Bose National Centre for Basic Sciences (S N Bose) introduced an artificial intelligence (AI) framework that could change how we understand and treat cancer, and also pave the way for personalised therapies.
- The framework, developed in collaboration with Ashoka University, gives a new lens to look at cancer -- not by its size or spread alone, but by its molecular personality.
- The new AI framework titled OncoMark can read the molecular “mind” of cancer and predict its behaviour.
- The team at S N Bose, led by Dr. Shubhasis Haldar and Dr. Debayan Gupta, used OncoMark to analyse 3.1 million single cells across 14 cancer types.
- S N Bose is an autonomous institute of the Department of Science and Technology (DST).
- OncoMark achieved over 99 per cent accuracy in internal testing and remained above 96 per cent across five independent cohorts.
- It was validated on 20,000 real-world patient samples from eight major datasets, showing broad applicability.
- The new framework, published in the Nature journal Communications Biology, reveals which hallmarks are active in a patient's tumour.
- Initiative offers a customised biomarker test panel for Acute Myeloid Leukaemia (AML) and Cholangiocarcinoma (CCA) across India at subsidised rates
- IDH1 and IDH2 mutation tests for both cancers provided free of cost to patients in the government sector
- Partnership involves Servier India, MedGenome and Strand Life Sciences to expand molecular testing access beyond urban centres
- Programme launched under Servier Care patient-support platform providing financial assistance and subsidised diagnostics where legally permissible
- Early molecular testing aims to guide precision oncology treatment decisions and improve survival rates in AML and CCA
- NexCAR19 is India’s first indigenous CAR-T cell therapy, developed by ImmunoACT, an IIT Bombay spin-off.
- The therapy was supported by the Department of Biotechnology (DBT) and the Biotechnology Industry Research Assistance Council (BIRAC).
- NexCAR19 is described as the world’s first humanised CAR-T therapy developed in India.
- Clinical trials conducted at Tata Memorial Centre have shown promising results in treating blood cancers like Acute Lymphocytic Leukemia (ALL).
- The therapy reprograms a patient’s own immune cells to fight cancer, representing India’s first “living drug.”